It is anticipated that, in the coming five years, several new TB drugs and regimens will need to be adopted and rolled out at the country level. While there is broad modelling work at the global level examining the impact and economic consequences of new regimens, there has been little examination of the optimal strategy for actually rolling out these regimens. This work aims to fill this gap, by investigating and comparing the health outcomes and economic consequences of expansive vs limited roll-out strategies in a number of settings. As this would be the first work in this area, and data are scarce, this work will be exploratory in nature, and should guide both future data needs and a approach for using modelling to best support early adopters of novel TB regimens.
This is the third of four research questions identified for potential funding at the recent TB MAC meeting on 'Modelling to support rational introduction of new drugs and regimens'.